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Kleij

Research group


Abstract

Our research activities currently focus on the valorization/upgrading of carbon dioxide and renewable feedstocks into value-added organic molecules using rational organocatalytic and metal-mediated catalytic approaches. In order to achieve these goals we use highly functional organic cyclic carbonates as versatile and accessible synthetic precursors. A primary focus is on sustainable solutions thereby improving on (1) overall activity and chemo-selectivity, and (2) stereo-chemical challenges. Our targeted portfolio of organic structures includes complex organic carbonates, allylic derivatives, amino acids and propargylic compounds through innovative stereo-selective or enantioselective coupling approaches. An important part of our work puts attention to new catalyst design and efforts to reach a higher level of mechanistic understanding concerning the observed reactivity/selectivity features through experimental and computational studies. Interdisciplinary collaborations with the industrial in the area of biobased polymers also form part of our activities in order to be able to transfer technological advancements from bench to and beyond pilot scale.

Topics addressed

  • Cyclic carbonates
  • Fine chemical synthesis
  • Bio-based polymers

Articles

“Pd-Catalyzed Enantio- and Regioselective Formation of Allylic Aryl Ethers “
Org. Lett. (2017) 19 – 6388-6391
J. Xie, W. Guo, A. Cai, E.C. Escudero-AdĂĄn, A.W. Kleij

“Copper-Mediated SN2â€Č Allyl−Alkyl and Allyl−Boryl Couplings of Vinyl Cyclic Carbonates
Org. Lett. (2017) 19 – 6096-6099
N. Miralles, J.E. GĂłmez, A.W. Kleij, E. FernĂĄndez

“Polystyrene-supported bifunctional resorcinarenes as cheap, metal-free and recyclable catalysts for epoxide/CO2 coupling reactions”
Green Chem. (2017) 19 – 5488-5493
T. Jose, S. Cañellas, M.A. Pericàs, A.W. Kleij

ICIQ