Melchiorre
Research group
Abstract
The group’s research interests are broadly based on the use of enantioselective organocatalysis (which involves only organic elements in the active principle) for the preparation of chiral molecules. Our strategy relies on the combination organocatalysis and visible light photocatalysis, two powerful strategies of modern chemical research with great potential for the sustainable preparation of organic molecules. The main focus is on the discovery and mechanistic elucidation of new enantioselective organocatalytic and photochemical processes that address unsolved problems in synthetic methodology. The final aim is to develop environmentally friendly and innovative catalytic methods that can find widespread use in modern organic synthesis.
Topics addressed
- Enantioselective Photo-organocatalysis
Articles
“Visible-Light Excitation of Iminium Ions Enables the Enantioselective β-Alkylation of Enals”
Nature Chem. (2017) 9, 868–873
Mattia Silvi, Charlie Verrier, Yannick Rey, Luca Buzzetti, Paolo Melchiorre
“Studies on the Enantioselective Iminium Ion Trapping of Radicals Triggered by an Electron-Relay Mechanism”
J. Am. Chem. Soc. (2017) 139, 4559-4567
Ana Bahamonde, John J. Murphy, Marika Savarese, Erik Bremond, Andrea Cavalli, Paolo Melchiorre
“Radical-based C-C Bond-Forming Processes Enabled by the Photoexcitation of 4-Alkyl-1,4-dihydropyridines”
Angew. Chem. Int. Ed. (2017) 56, 15039–15043 Luca Buzzetti, Alexis Prieto, Sudipta R. Roy, Paolo Melchiorre
“Forging Quaternary Fluorine Stereocenters by a Light-driven Organocatalytic Aldol Desymmetrization Process”
Angew. Chem. Int. Ed. (2017) 56, 11875–11879 Sara Cuadros, Luca Dell’Amico, Paolo Melchiorre
“Enantioselective Formal α-Methylation and α-Benzylation of Aldehydes by Means of Photo-Organocatalysis”
Angew. Chem. Int. Ed. (2017) 56, 4447–4451 Giacomo Filippini, Mattia Silvi, Paolo Melchiorre
“Light-Driven Enantioselective Organocatalytic β-Benzylation of Enals”
Angew. Chem. Int. Ed. (2017) 56, 3304–3308 Luca Dell’Amico, Victor M. Fernández-Alvarez, Feliu Maseras, Paolo Melchiorre
“Light-triggered Enantioselective Organocatalytic Mannich-type Reaction”
Synthesis (2017) 49, 76-86
Hamish B. Hepburn, Giandomenico Magagnano, Paolo Melchiorre